Abstract: In order to solve the problems, such as the low machining efficiency, short service life of abrasive tools, and poor ground surface quality, brazed cubic boron nitride (CBN) porous abrasive wheels coupled with high porosity, good wear resistance and excellent self-sharpening ability were fabricated. Open pore structures were designed, and then the grinding performance and wear experiments were conducted in grinding of Ti-6Al-4V titanium alloys. Grindability and ground surface quality of Ti-6Al-4V alloys affected by grinding parameters were discussed in detail. In addition, the self-sharpening ability of brazed CBN porous abrasive wheels was analyzed. Results shows that brazed CBN porous abrasive wheels featured a desired flexural strength and excellent chip storage space after optimizing the pore size of 0.6~0.8 mm and designed porosity of 40%. The brazed CBN porous abrasive wheels showed a more stable grinding force ratio from 1.5 to 2.2 with the grinding speed of 80 m/s compared to that with the grinding speed of 30 m/s. Moreover, with the increase of material removal volume, the ground surface roughness rapidly declined and stabilized due to the stabilization of the dynamic effective grains number.