Abstract: The formability of vitrified CBN grinding wheel mixture is directly affected by wetting agent, which further affects the microstructure uniformity of grinding wheel. In this study, four new wetting agents, PVB ethanol solution, PAM water solution, PEG-6000 water solution and ISOBAM-110 water solution, were selected to compare with dextrin solution. The effects of these wetting agents on mixture uniformity, loose density, strength and microstructure of vitrified CBN grinding wheel mixture were studied. The results show that the mixtures with ISOBAM-110 and PAM are uniform, whose loose density are increased by 46.59% and 51.14% respectively with the strength of the segment increased by 17.71% and 35.08% and the inhomogeneity of grinding wheel decreased by 23.75% and 8.75%. The properties of the mixtures are improved obviously compared with dextrin solution.